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SedLine monitor scan

About SedLine

SedLine® brain function monitoring advances neuromonitoring technologies to improve the care of patients under anesthesia or sedation. The core product is a state-of-the-art EEG-based brain function monitor. Utilizing 4 channels of information, the SedLine monitor measures the effects of anesthesia and sedation by monitoring both sides of the brain s electrical activity to enable more individualized titration and improve the care of patients under anesthesia or sedation.

In 2010, Masimo acquired SedLine, commercialized SedLine products through its worldwide distribution channels, and initiated next-generation brain function monitoring technology and product development.

EEG and Anesthesia

Quantitative EEG (QEEG) Measures of Brain Activity in Response to Sedation/Anesthesia Follow a Predictable Pattern

  • > As the brain falls asleep, EEG activity declines according to a specific, invariant pattern1
    • • In general, this drop in activity begins in the frontal lobes and moves toward the back of the brain

Shifts in EEG Power at Induction and Loss of Consciousness (LOC)

Chart showing shifts in EEG power at induction and loss of consciousness

These VARETA images depict changes in Delta wave (i.e., 3 to 5 Hz) activity. Anesthesia (propofol shown here) spreads from the frontal lobes toward the back of the brain (note residual blue/white at induction). Even at LOC, the frontal lobes are more heavily anesthetized areas.

  • > When waking up, EEG activity increases across the brain in exactly the opposite sequence observed when falling asleep
  • > These activity patterns have been shown to be invariant across a range of patient types and sedative/anesthetic agents1
    • • Propofol
    • • Inhalation gas - Isoflurane, Sevoflurane and Desflurane
    • • Nitrous/narcotic

PSI Algorithm

A Sophisticated Algorithm

The SedLine device uses a sophisticated multivariate algorithm to assess the patient s EEG data from all 4 channels and determine the Patient State Index (PSI) value as a measure of anesthetic depth.

SedLine technology is based on more than 10 years of technical and clinical development. The algorithm is based on extensive EEG records developed by the Brain Research Laboratory at New York University School of Medicine. The sensor technology was developed to improve the acquisition of EEG signals and was used in NASA s Sleep Studies in 1998. By providing an integrated algorithm based upon 4-channels of EEG data, demonstrated reliability under challenging clinical conditions and superior resistance to cautery, the SedLine monitor system offers a cost-effective alternative to other monitors. The system is currently in use at some of the nation s leading healthcare institutions.

Chart illustrating the PSI algorithm

Grounded in Sound Science

The algorithm relies upon stepwise comparisons against extensive EEG records developed by the Brain Research Laboratory at New York University School of Medicine. These records encompass five databases with patient data recorded under a variety of clinical and anesthetic conditions.

Using EEG Data From Both Sides of the Brain

Multiple sub-algorithms enhance the sensitivity of PSI algorithm to changes in activity. The "arousal observer" sub-algorithm detects subtle early changes in EEG that signify decreasing sedation. This sub-algorithm also scrutinizes changes in activity occurring between pairs of leads for evidence of patterns signaling waning sedation levels.

Read PSI 25-50 Range of Optimal Hypnotic State for General Anesthesia to learn more about the studies supporting the development of the algorithm.

PSI Guidelines

A Greater Volume of Data to Enhance Your Anesthetic Control

Brain function monitoring with SedLine helps the anesthesia provider deliver the desired level of targeted sedation throughout all phases of anesthesia. SedLine uses a sophisticated algorithm based on extensive EEG records to process EEG data and determine the PSI value as a measure of anesthetic depth. The PSI corresponds to a patient s current level of sedation/anesthesia along a scale of 0 to 100, where 100 represents being fully awake2. Guidelines for interpreting the full range of values are presented below. ReadPSI 25-50 Range of Optimal Hypnotic State for General Anesthesia to learn more about the studies supporting the development of these guidelines.

The PSI values reflect loss of consciousness, arousals, emergence and response to noxious stimuli. For ease in use, the numeric PSI values are color coded on the display to promote immediate assessment of patient status. 4-channel real-time EEG data is presented as waveforms and as a Density Spectral Array (DSA) to enable quick and easy confirmation of PSI values.

Chart of guidelines for PSI values